Implications of all the available evidenceĬOVID-19 vaccination programs are currently focused on expanding coverage in eligible populations as quickly as possible within the constraint of vaccine availability, without adjusting for prior immunity or exposure, and largely without validation of individual or population-based immune responses to the different vaccines.
Twenty-nine published studies and four preprints were identified in this search, but none of the studies report a deployable, visual point of care test for measuring protective levels of SARS-CoV-2 protection. We searched PubMed up to 11 October 2021 using the search terms (“SARS-CoV-2” OR “COVID-19”) AND ("neutralizing antibody") AND (“lateral flow” OR “point of care”), and also manually searched references in the relevant papers to identify preprints. There are a number of laboratory-based methods for measuring SARS-CoV-2 immunity in individuals and populations, but there is an unmet need for methods that can be used at the point of care to support improved control efforts including quarantine, vaccination, and boosting as required. Widespread deployment of efficacious COVID-19 vaccines has contributed to much lower disease rates in many wealthy countries, but most countries and especially low and middle-income countries (LMICs) are facing new waves of SARS-CoV-2 infection driven by factors including limited access to vaccines, variable efficacy for some of the available vaccines, and the emergence of viral variants of concern (VOCs).
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